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. 2021 Jan 12;218(3):e20202135. doi: 10.1084/jem.20202135

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© 2021 Song et al.

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Figure 8. — Evidence of neuroinvasion in postmortem COVID-19 patient brains. FFPE sections of brain tissue from COVID-19 patients stained with H&E and anti–SARS-CoV-2-spike antibody. (A) Image of cortical neurons positive for SARS-CoV-2 (black arrows). Scale bar = 20 µm. (B) Images of unaffected regions (left) and infected regions (right) demonstrating infection of neurons (top row) and microvasculature (bottom row). Scale bar = 20 µm. (C) Ischemic infarcts found at different stages stained with H&E (top row) and SARS-CoV-2-spike antibody (bottom row). (D) Ischemic region (outlined with dotted line) with positive staining focused around ischemic infarct. Bottom image shows zoomed-in image indicated by dotted box in top image, and black arrows indicate infected neurons in the region. (E) Schematic of hypothesized consequences of SARS-CoV-2 neuroinvasion.