Table 1. Clinical characteristics of COVID-19 patients.

	Patient 1	Patient 2	Patient 3
Gender	Male	Male	Female
Age (yr)	63	58	49
Medical history	Hypertension (no treatment)	Obesity	Renal transplantation (immunosuppressive therapy)
		Hypertension	Type 1 diabetes
		Sleep apnea syndrome	Hypertension
		Pneumonia (2017)	Pulmonary embolism (2003)
Onset of illness	Day 0: Dyspnea and fever	Day 0: Diarrhea, asthenia	Day 0: Fever, dyspnea, cough, sputum
		Day 16: Chills and dyspnea
	SARS-CoV-2 PCR test positive	No SARS-CoV-2 PCR test	Day 1: Nasal SARS-CoV-2 PCR test positive
Emergency department admission	Day 10: Worsening dyspnea → patient sedated and ventilated
ICU admission	Day 10: Acute respiratory distress and left myocardial failure	Day 18: Acute respiratory distress and fever → patient sedated and ventilated	Day 3: Dyspnea; mechanical ventilation
			Day 5: Moderate acute respiratory distress syndrome; kidney failure
Medical course	Day 14: Difficulty waking the patient after cessation of sedation = areactive encephalopathy	Resuscitated hypoxic cardiac arrest due to aspiration during initial care	Difficult ventilator withdrawal
		Compressive pneumothorax; refractory cardiac arrests	Day 16: Bacterial pneumoniae; transfer to the rehabilitation service
		No SARS-CoV-2 PCR test during hospitalization	Day 19: Acute respiratory distress and kidney failure → transfer to ICU
Brain imaging	Day 32: Brain MRI; multiple diffuse micro bleedings (subcortical and deep regions)	No brain imaging	No brain imaging
Death	Day 43	Day 19 (after 6–12 h of hospital medical care)	Day 27
Postmortem SARS-CoV-2 PCR test on lungs	Positive	Positive	Positive

ICU, intensive care unit; MRI, magnetic resonance imaging.