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. Author manuscript; available in PMC: 2021 Dec 16.
Published in final edited form as: Sci Transl Med. 2020 Dec 16;12(574):eaax3519. doi: 10.1126/scitranslmed.aax3519

Figure 1. A polymorphism in human CHI3L1 impacts rate of AD progression.

Figure 1.

A. Single nucleus RNAseq tSNE plot showing cell clusters (top panel) or CHI3L1 expression (purple, bottom panel). Ex = excitatory neuron, In = Inhibitory neuron, OPC = oligodendrocyte precursor cells, Endo = endothelial cells. Data available at http://ngi.pub/snuclRNA-seq/.

B. CHI3L1 expression by cell cluster from data in (A). ****P=3×10−280.

C. AD progression (change in CDR-SB) from human patients with and without the CC_TT polymorphism of the Rs10399931 SNP in CHI3L1.