TABLE 1.
Baseline Characteristics of Women Who Received 5 Years of Adherent BP Treatment
| Characteristics | All Women | Index Year (Year of Cohort Entry) | |
|---|---|---|---|
| < 2008 | > 2008 | ||
| Number of women, n | 19,091 | 4,830 | 14,261 |
| Age, median (IQR) | 72 (65-78) | 72 (65-78) | 72 (65-78) |
| Race/ethnicity, n (%) | |||
| White | 11,076 (58.0) | 3,268 (67.7) | 7,808 (54.8) |
| African American/black | 1,015 (5.3) | 168 (3.5) | 847 (5.9) |
| Hispanic/Latina | 3,008 (15.8) | 491 (10.2) | 2,517 (17.6) |
| Asian/Pacific Islander | 3,332 (17.5) | 695 (14.4) | 2,637 (18.5) |
| Other/mixed/unknown | 660 (3.5) | 208 (4.3) | 452 (3.2) |
| Index BMI category (kg/m2), n (%) | |||
| Normal/underweight (BMI < 25) | 10,207 (53.5) | 2,657 (55.0) | 7,550 (52.9) |
| Overweight (BMI 25-< 30) | 5,549 (29.1) | 1,124 (23.3) | 4,425 (31.0) |
| Obese (BMI ≥ 30) | 2,700 (14.1) | 436 (9.0) | 2,264 (15.9) |
| Unknown | 635 (3.3) | 613 (12.7) | 22 (0.2) |
| Charlson Comorbidity Index score, n (%) | |||
| 0 | 11,404 (59.7) | 3,245 (67.2) | 8,159 (57.2) |
| 1-2 | 5,658 (29.6) | 1,284 (26.6) | 4,374 (30.7) |
| > 2 | 2,029 (10.6) | 301 (6.2) | 1,728 (12.1) |
| History of medical conditions, n (%) | |||
| Diabetes | 1,939 (10.2) | 247 (5.1) | 1,692 (11.9) |
| Rheumatoid arthritis | 552 (2.9) | 195 (4.04) | 357 (2.5) |
| Grade 3 chronic kidney disease | 3,152 (16.5) | 804 (16.6) | 2,348 (16.5) |
| Other medication use, n (%) | |||
| Proton pump inhibitors | 509 (2.7) | 96 (2.0) | 413 (2.9) |
| Aromatase inhibitors | 13 (0.1) | 1 (0) | 12 (0.1) |
| Glucocorticoids | 1,170 (6.1) | 375 (7.8) | 795 (5.6) |
| Fracture history, n (%) | |||
| Before BP initiation | |||
| Major osteoporotic fracturesa | 1,495 (7.8) | 329 (6.8) | 1,166 (8.2) |
| Any clinical fracture | 3177 (16.6) | 580 (12.0) | 2,597 (18.2) |
| Within 5 years before cohort entry | |||
| Major osteoporotic fracturesa | 1,664 (8.7) | 408 (8.4) | 1,256 (8.8) |
| Any clinical fracture | 3,170 (16.6) | 824 (17.1) | 2,346 (16.5) |
| Bone mineral density | |||
| DXA tested, n (%) | 15,459 (81.0) | 3,356 (69.5) | 12,103 (84.9) |
| T-score, median (IQR) | -2.4 (-2.9 to -2.0) | -2.6 (-3.1 to -2.1) | -2.4 (-2.9 to -2.0) |
| Osteoporosis, n (%) | 7,047 (45.6) | 1,869 (55.7) | 5,178 (42.8) |
| Osteopenia, n (%) | 8,006 (51.8) | 1,351 (40.3) | 6655 (55.0) |
aIncludes fractures of the hip, humerus, wrist, or spine.
BMI = body mass index; BP = bisphosphonate; DXA = dual-energy x-ray absorptiometry scan; IQR = interquartile range.