TABLE 2.
Multivariable Adjusted ORs for Continuing Treatment Among Women Receiving BP
| Predictor | OR (95% CI) |
|---|---|
| Age, years | |
| 50-59 | 1 |
| 60-69 | 0.98 (0.92-1.04) |
| 70-79 | 1.06 (1.00-1.13) |
| ≥ 80 | 1.00 (0.93-1.07) |
| Race/ethnicity | |
| White | 1 |
| African American/black | 0.93 (0.86-1.01) |
| Hispanic/Latina | 0.89 (0.85-0.94) |
| Asian/Pacific Islander | 0.90 (0.85-0.94) |
| Current smoking | 1.04 (0.96-1.14) |
| Low education census block | 1.04 (0.99-1.10) |
| Low income census block | 1.05 (0.97-1.13) |
| Index year (year of cohort entry) < 2008 | 1.35 (1.29-1.41) |
| BMI category (kg/m2) | |
| Normal/underweight (BMI < 25) | 1 |
| Overweight (BMI 25-< 30) | 0.99 (0.95-1.03) |
| Obese (BMI ≥ 30) | 1.00 (0.94-1.05) |
| Charlson Comorbidity Index score | |
| 0 | 1 |
| 1 | 0.99 (0.94-1.05) |
| 2 | 0.97 (0.91-1.03) |
| > 2 | 0.91 (0.84-0.98) |
| History of medical conditions | |
| Diabetes | 1.08 (1.01-1.16) |
| Rheumatoid arthritis | 0.89 (0.80-0.99) |
| Chronic kidney disease | |
| Grade 3a | 1.00 (0.95-1.06) |
| Grade 3b | 0.91 (0.82-1.00) |
| Other medication use | |
| Proton pump inhibitors | 0.65 (0.59-0.71) |
| Aromatase inhibitors | 0.92 (0.69-1.24) |
| Glucocorticoids | 1.01 (0.89-1.13) |
| History of fractures before BP initiation | |
| Hip | 0.90 (0.80-1.01) |
| Spine | 0.98 (0.84-1.15) |
| Humerus | 0.95 (0.82-1.10) |
| Wrist | 1.06 (0.94-1.18) |
| Other skeletal site | 0.95 (0.90-1.01) |
| History of fractures in previous 12 months | |
| Hip | 0.61 (0.52-0.71) |
| Spine | 0.87 (0.76-1.00) |
| Humerus | 0.79 (0.66-0.94) |
| Wrist | 1.11 (0.96-1.28) |
| Other skeletal site | 0.90 (0.84-0.97) |
| BMD T-score | |
| > −2.0 | 1 |
| −2.0 to > −2.5 | 1.31 (1.25-1.38) |
| −2.5 to > −3.0 | 1.48 (1.39-1.57) |
| ≤ −3.0 | 1.57 (1.47-1.68) |
| Time on follow-up | |
| < 6 months | 1 |
| 6 months to 1 year | 1.16 (1.09-1.24) |
| Year 2 | 1.24 (1.18-1.31) |
| Year 3 | 1.29 (1.21-1.36) |
| Year 4 | 1.27 (1.19-1.36) |
| Year 5 | 1.26 (1.17-1.36) |
BMD = bone mineral density; BMI = body ma ss index; BP = bisphosphonate; CI = confidence inter val; OR = odds ratio.