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. 2020 Aug 6;162(2):514–530. doi: 10.1097/j.pain.0000000000002031

Figure 1.

Figure 1.

Effects of acupuncture on mechanical hyperalgesia and cold allodynia, evaluated using the von Frey and acetone tests. The effects of acupuncture treatment (acupoints GB30 [Hwando] and GB34 [Yanglingquan]; AP group), stimulation of nonacupoints (CP group) (A), and amitriptyline (PC group, 10 mg/kg, intraperitoneally [i.p.]) applied 3 days/week for 6 months on mechanical hyperalgesia and cold allodynia were investigated using the von Frey (B) and cold (acetone) (C) tests in a partial sciatic nerve ligation (PSNL)-induced neuropathic pain model. The antiallodynic effects of AP, CP, and PC (10 mg/kg, i.p.) were measured on the ipsilateral plantar surfaces 2 hours after administration (for 0, 1, and 2 weeks, and 1-6 months) (n = 22/group. *P < 0.05, **P < 0.01, ***P < 0.001 vs the PSNL group, and ###P < 0.001 vs the AP group). Data were analyzed using two-way repeated-measures analysis of variance (ANOVA) followed by Bonferroni post hoc test. The results are expressed as the mean ± SEM. AP, acupuncture points; CP, control point; PC, positive control.