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. 2020 Sep 10;162(2):641–652. doi: 10.1097/j.pain.0000000000002064

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Figure 2. — Dorsal lateral prefrontal cortex GMV reduction in FM patients is related to symptom duration. (A) VBM analysis of GMV comparing HCs and FM patients showed significant increases within the left dorsolateral prefrontal cortex (DLPFC) indicating DLPFC GMV reduction in FM patients (age-corrected, cluster forming threshold z > 3.1, cluster correction P < 0.05; 1461 voxels; peak z-score = 4.8, P = 0.002; MNI coordinates −30, 4, 44). (B) Average GMV of the DLPFC in FM patients significantly correlated negatively with the duration of fibromyalgia symptoms. (C) A trend towards a negative correlation between DLPFC GMV and symptom duration remained after correcting for age. FM, fibromyalgia; GMV, gray matter volume; HCs, healthy controls; L, left.