Table 2.
Whole-brain blood oxygenation level-dependent responses during the first heat stimulation periods.
| Region | Voxels | MNI coordinates | Peak z-score | P | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Control > baseline | ||||||
| Insula (R) | 46,636 | 28 | 65 | 39 | 9.01 | <0.001 |
| Nucleus accumbens (R) | 39 | 68 | 34 | 5.40 | ||
| ACC | 49 | 70 | 53 | 7.07 | ||
| Insula (L) | 60 | 72 | 38 | 8.05 | ||
| Occipital ctx (L) | 53 | 21 | 27 | 8.94 | ||
| Occipital ctx (R) | 28 | 17 | 43 | 8.33 | ||
| SI (R) | 37 | 43 | 70 | 6.84 | ||
| SII (L) | 74 | 52 | 44 | 7.77 | ||
| SII (R) | 18 | 51 | 45 | 7.74 | ||
| Thalamus (R) | 40 | 59 | 38 | 6.70 | ||
| Placebo > baseline | ||||||
| Planum polare | 43,617 | 18 | 65 | 35 | 9.38 | <0.001 |
| Nucleus accumbens (R) | 40 | 67 | 33 | 6.54 | ||
| ACC | 49 | 73 | 51 | 7.16 | ||
| Insula (R) | 27 | 74 | 34 | 8.65 | ||
| Insula (L) | 64 | 54 | 39 | 7.15 | ||
| Occipital ctx (L) | 52 | 20 | 29 | 8.38 | ||
| Occipital ctx (R) | 31 | 16 | 43 | 7.68 | ||
| SI (R) | 39 | 44 | 70 | 6.15 | ||
| SII (L) | 76 | 51 | 44 | 6.50 | ||
| SII (R) | 15 | 49 | 47 | 6.81 | ||
| Control > placebo | ||||||
| Occipital ctx (L) | 1710 | 53 | 12 | 37 | 4.69 | <0.001 |
| Occipital ctx (R) | 1624 | 37 | 14 | 39 | 5.89 | <0.001 |
| Posterior insula (R) | 1474 | 26 | 55 | 42 | 4.59 | <0.001 |
| Midanterior insula (R) | 27 | 70 | 38 | 3.74 | ||
| SII (R) | 20 | 49 | 45 | 4.17 | ||
| SII (L) | 1197 | 79 | 50 | 44 | 4.34 | <0.001 |
| Placebo > control | ||||||
| — | — | — | — | — | — | — |
| Group × cream (F-test) | ||||||
| — | — | — | — | — | — | — |
| Group × cream × drug (F-test) | ||||||
| — | — | — | — | — | — | — |
(L), left; (R), right; ACC, anterior cingulate cortex; ctx, cortex; SI, primary somatosensory cortex; SII, secondary somatosensory cortex.