Table 5.
Best subsets of factors (as measured in RS1) for predicting overall change in pain intensity and CRPS severity throughout the study period (intention-to-treat analysis).
| Best subsets models | Adj. R2 | AIC | CV |
|---|---|---|---|
| Change in pain intensity† | |||
| Model 1: (+) absolute change in handedness* | 0.09 | −132.24 | 0.28 |
| Model 2: (+) absolute change in handedness,* (+) index A of directional bradykinesia for the unaffected hand | 0.13 | −119.08 | 0.29 |
| Model 3: (+) oedema difference,** (−) index B of directional hypokinesia for the affected hand,** (−) delta finger-to-palm distance ratio* | 0.25 | −105.79 | 0.30 |
| Model 4: (+) oedema difference,** (−) index B of directional hypokinesia for the affected hand,* (−) delta finger-to-palm distance ratio,* (+) mood disturbance | 0.27 | −105.68 | 0.30 |
| Model 5: (+) oedema difference,** (−) index B of directional hypokinesia for the affected hand,** (+) Mental Number Line Bisection score,* (+) absolute change in handedness, (−) delta finger-to-palm distance ratio | 0.32 | −107.60 | 0.35 |
| Change in CRPS severity† | |||
| Model 1: (+) current pain intensity** | 0.13 | −50.21 | 0.58 |
| Model 2: (+) current pain intensity,** (−) index B of directional bradykinesia for the unaffected hand* | 0.23 | −48.39 | 0.60 |
| Model 3: (+) current pain intensity,*** (+) oedema difference,* (+) hand laterality recognition accuracy index* | 0.25 | −55.52 | 0.54 |
| Model 4: (+) allodynia on the affected limb,* (−) index B of directional bradykinesia for the unaffected hand,* (−) index B of directional hypokinesia for the unaffected limb,* (+) disease duration | 0.21 | −45.66 | 0.62 |
| Model 5: (−) index B of directional bradykinesia for the unaffected hand,* (−) index B of directional hypokinesia for the unaffected limb, (+) allodynia on the affected limb, (+) disease duration, (+) body perception disturbance score | 0.21 | −44.84 | 0.62 |
Figures in bold indicate the lowest AIC and CV.
* P < 0.05, ** P < 0.01, and *** P < 0.001 indicate significant predictors; (+), positive predictor; (−), negative predictor.
Predicted outcomes were quantified as individual regression slopes based on pain intensity ratings throughout RS1-RS4 and LTFU1-LTFU2 and CRPS severity scores throughout RS1-RS4 (negative slopes indicate reductions in pain/CRPS severity).
Adj. R2, adjusted R-squared; AIC, Akaike information criterion; CRPS, complex regional pain syndrome; CV, cross-validation error; LTFU1 and LTFU2, long-term follow-ups 1 and 2; RS, RS1, RS2, RS3, and RS4, research sessions 1, 2, 3, and 4.