Figure 1.

An example of two antibodies that bind to the same epitope but derive from different clonotypes. The murine 4C2 (PDB ID: 5do2) and D12 (PDB ID: 4zpv) anti-MERS-CoV antibodies target the same residues on the receptor-binding domain of the spike protein, which can be seen from alignment of their antibody/antigen complex structures (a). 4C2 and D12 use over 80% of the same heavy chain paratope residues (b) and target 95% of the same epitope residues (c). The antibodies are derived from different IGHV and IGHJ genes and display CDRH3 amino acid identity (66.7%) below standard clonotyping definitions (80–100%)⁵ (d), so would not be considered within the same clonotype