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. 2020 Oct 15;370(6521):eabe9403. doi: 10.1126/science.abe9403

Fig. 1. Coronavirus genome annotations and integrative analysis overview.

Fig. 1

(A) Genome annotation of SARS-CoV-2, SARS-CoV-1, and MERS-CoV with putative protein coding genes highlighted. Intensity of filled color indicates the lowest sequence identity between SARS-CoV-2 and SARS-CoV-1 or between SARS-CoV-2 and MERS. (B to D) Genome annotation of structural protein genes for SARS-CoV-2 (B), SARS-CoV-1 (C), and MERS-CoV (D). Color intensity indicates sequence identity to specified virus. (E) Overview of comparative coronavirus analysis. Proteins from SARS-CoV-2, SARS-CoV-1, and MERS-CoV were analyzed for their protein interactions and subcellular localization, and these data were integrated for comparative host interaction network analysis, followed by functional, structural, and clinical data analyses for exemplary virus-specific and pan-viral interactions. The asterisk indicates that the SARS-CoV-2 interactome was previously published in a separate study (5). SARS, both SARS-CoV-1 and SARS-CoV-2; MERS, MERS-CoV; Nsp, nonstructural protein; ORF, open reading frame.