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. 2020 Oct 15;370(6521):eabe9403. doi: 10.1126/science.abe9403

Fig. 8. SARS-CoV-2 ORF8 and functional interactor IL17RA are linked to viral outcomes.

Fig. 8

(A) IL17RA and ADAM9 are functional interactors of SARS-CoV-2 ORF8. Only interactors identified in the genetic screening are shown. (B) Coimmunoprecipitation of endogenous IL17RA with Strep-tagged ORF8 or EGFP with or without IL-17A treatment at different times. Overexpression was done in HEK293T cells. (C) Viral titer after IL17RA or control knockdown in A549-ACE2 cells. (D) OR of membership in indicated cohorts by genetically predicted sIL17RA levels. SARS2, SARS-CoV-2; IP, immunoprecipitation; SD, standard deviation; OR, odds ratio; CI, confidence interval; sIL17RA, soluble IL17RA. *P < 0.05, unpaired t test. Error bars in (C) indicate SDs; in (D), they indicate 95% CIs.