Figure 1.

Phylogenetic tree of fungal trehalases. Two main clusters can be distinguished: the neutral trehalases and the acid trehalases. The human trehalase enzyme was included and is present in the cluster of neutral trehalase enzymes. Protein sequences were aligned and the phylogenetic tree was constructed using the unweighted pair method with arithmetic mean (UPGMA) and the Kimura Protein as a protein distance measure (a). Overview of amino acid identity between the C. glabrata and S. cerevisiae trehalases (b)