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. 2021 Jan 8;13(1):1854967. doi: 10.1080/19490976.2020.1854967

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The causal relationship between SNVs, microbes, and metabolites

(A) The causal relationship of SNV-microbe-metabolite trios inferred by causal inference test. The red and green links represent positive and negative assoications, respectively.(B) The abundance of Faecalibacterium prausnitzi related to PGLYRP4a SNV status, and the correlation between Faecalibacterium prausnitzi and Dopaquinone and 2ʹ-Deoxyguanosine.(C) The abundance of Bacteroides ovatus related to SNV status of LILRA6 and the correlation between Bacteroides ovatus and Desaminotyrosine, Tyrosyl-Leucine, and 3-(Uracil-1- yl)-L- alanine.