Figure 2.

Host lipid raft mediated Signaling modulation: Pseudomonas aeruginosa upon binding to cystic fibrosis transmembrane conductance regulator (CFTR) and triggers activity of acid sphingomyelinase (ASM). ASM then leads to the production of ceramide in a CD40 and CD95 mediated pathway, which remains knitted with lipid rafts clustering and activation of downstream signaling to inhibit IL-1β expression and thus again inducing CD95 dependent apoptosis