Table 4.
Overall meta-analysis of the association between breast cancer and miR-27a polymorphism.
| Heterogeneity of study design | ||||||
| Genetic model | OR [95% CI] | Z (P) | c2 | df (P) | I2 (%) | Analysis model |
| miR-27a rs895819 in total population from 16 case control studies (6118 cases and 7042 controls) | ||||||
| Allelic model (G-allele vs A-allele) | 0.92 [0.84, 1.00] | 1.95 (.05) | 32.77 | 15 (.005) | 54 | Random |
| Recessive model (GG vs. AG+AA) | 0.88 [0.74, 1.03] | 1.56 (.12) | 25.30 | 15 (.05) | 41 | Random |
| Dominant model (AA vs. AG+GG) | 1.09 [0.97, 1.23] | 1.49 (.14) | 35.02 | 15 (.002) | 57 | Random |
| Homozygous model (GG vs AA) | 0.87 [0.73, 1.04] | 1.57 (.12) | 25.40 | 15 (.04) | 41 | Random |
| Heterozygous model (AG vs AA) | 0.92 [0.82, 1.05] | 1.25 (.21) | 35.45 | 15 (.002) | 58 | Random |
| miR-27a rs895819 in Asian population from 11 case–control studies (2898 cases and 2600 controls) | ||||||
| Allelic model (G-allele vs A-allele) | 0.92 [0.80, 1.05] | 1.23 (.22) | 26.46 | 10 (.003) | 62 | Random |
| Recessive model (GG vs AG + AA) | 0.86 [0.67, 1.12] | 1.11 (.27) | 19.81 | 10 (.03) | 50 | Random |
| Dominant model (AA vs AG + GG) | 1.08 [0.90, 1.31] | 0.82 (.41) | 28.02 | 10 (.002) | 64 | Random |
| Homozygous model (GG vs AA) | 0.88 [0.66, 1.16] | 0.91 (.36) | 20.64 | 10 (.02) | 52 | Random |
| Heterozygous model (AG vs AA) | 0.91 [0.75, 1.12] | 0.86 (.39) | 28.70 | 10 (.001) | 65 | Random |
| miR-27a rs895819 in Chinese population from 8 case–control studies (2328 cases and 2027 controls) | ||||||
| Allelic model (G-allele vs A-allele) | 0.98 [0.90, 1.08] | 0.33 (.74) | 5.81 | 7 (.56) | 0 | Fixed |
| Recessive model (GG vs AG + AA) | 0.94 [0.77, 1.15] | 0.56 (.57) | 5.88 | 7 (.55) | 0 | Fixed |
| Dominant model (AA vs AG + GG) | 1.00 [0.84, 1.19] | 0.01 (.99) | 13.08 | 7 (.07) | 46 | Random |
| Homozygous model (GG vs AA) | 1.01 [0.82, 1.25] | 0.11 (.91) | 1.76 | 7 (.97) | 0 | Fixed |
| Heterozygous model (AG vs AA) | 0.96 [0.76, 1.20] | 0.38 (.70) | 19.62 | 7 (.006) | 64 | Random |
| miR-27a rs895819 in Caucasian population from 5 case–control studies (3220 cases and 4442 controls) | ||||||
| Allelic model (G-allele vs A-allele) | 0.90 [0.84, 0.97] | 2.85 (.004) | 6.30 | 4 (.18) | 37 | Fixed |
| Recessive model (GG vs AG + AA) | 0.93 [0.80, 1.08] | 0.93 (.35) | 4.30 | 4 (.37) | 7 | Fixed |
| Dominant model (AA vs AG + GG) | 1.13 [1.03, 1.24] | 2.69 (.007) | 6.67 | 4 (.15) | 40 | Fixed |
| Homozygous model (GG vs AA) | 0.88 [0.75, 1.03] | 1.63 (.10) | 4.64 | 4 (.33) | 14 | Fixed |
| Heterozygous model (AG vs AA) | 0.89 [0.81, 0.98] | 2.29 (.02) | 6.62 | 4 (.16) | 40 | Fixed |
95% CI = 95% confidence interval, OR = odds ratio.