Table 1. Demographic, clinical and laboratory characteristics of patients with Coronavirus Disease-19 on hospital admission in the derivation and the validations cohorts.
| Overall (n = 2191) | Derivation cohort (n = 1810) | Validation cohort (n = 381) | p-value | |
|---|---|---|---|---|
| Age (years) | 67 (56–77) | 67 (55–78) | 68 (57–77) | 0.960 |
| <50 | 293 (13.4%) | 239 (13.2%) | 54 (14.2%) | |
| 50–59 | 394 (18.0%) | 312 (17.2%) | 82 (21.5%) | |
| 60–69 | 511 (23.3%) | 437 (24.1%) | 74 (19.4%) | |
| 70–79 | 594 (27.1%) | 510 (28.2%) | 84 (22.0%) | |
| >80 | 399 (18.2%) | 312 (17.2%) | 87 (22.8%) | |
| Male sex | 1521 (69.4%) | 1280 (70.7%) | 241 (63.3%) | 0.006 |
| Median duration of symptoms before hospital admission | 8 (5–11) | 8(2–10) | 7(5–11) | <0.0001 |
| Duration of symptoms before hospital admission shorter than 10 days | 1473 (67.2%) | 1193 (65.9%) | 280 (73.5%) | 0.004 |
| Fever | 1866 (85.2%) | 1495 (82.6%) | 371 (97.4%) | <0.0001 |
| Dyspnea | 1235 (56.4%) | 1070 (59.1%) | 165 (43.3%) | <0.0001 |
| Cough | 969 (44.2%) | 742 (41.0%) | 227 (59.5%) | <0.0001 |
| Diarrhea | 164 (7.5%) | 127 (7.0%) | 37 (9.7%) | 0.810 |
| Number of comorbidities | 0.250 | |||
| 0 | 1506 (71.4%) | 1233 (71.3%) | 273 (71.7%) | |
| 1 | 446 (21.1%) | 372 (21.5%) | 74 (19.4%) | |
| ≥ 2 | 157 (7.4%) | 123 (7.1%) | 34 (8.9%) | |
| Comorbidity | ||||
| Hypertension | 952 (43.4%) | 825 (45.6%) | 127 (33.3%) | <0.0001 |
| Diabetes | 372 (17.0%) | 311 (17.1%) | 61 (16.0%) | 0.370 |
| Obesity | 320 (14.6%) | 265 (14.6%) | 54 (14.1%) | 0.014 |
| Coronary Heart Disease | 209 (9.5%) | 159 (8.8%) | 43 (11.2%) | 0.230 |
| Chronic kidney disease | 164 (7.5%) | 124 (6.8%) | 40 (10.5%) | 0.047 |
| Chronic obstructive lung disease | 148 (6.8%) | 102 (5.6%) | 46 (12.1%) | 0.001 |
| Malignancy | 98 (4.5%) | 66 (3.6%) | 32 (8.4%) | 0.002 |
| Chronic Liver disease | 45 (2.0%) | 42 (2.3%) | 3 (0.7%) | 0.005 |
| Current smoker | 87 (4.0%) | 63 (3.5%) | 24 (6.3%) | 0.011 |
| Glutamic pyruvic transaminase, U/L | 54(108.61) | 57(120.05) | 44(57.04) | 0.003 |
| C-reactive protein, mg/dL | 11.5 (10.01) | 11.9 (10.33) | 10.1 (8.68) | 0.001 |
| C-reactive protein>10 mg/dL | 1438/1733 (83.0%) | 1145/1359 (84.3%) | 293/374 (78.3%) | 0.100 |
| Lactate dehydrogenase, U/L | 441 (323) | 462 (343) | 343 (173) | <0.0001 |
| Lactate dehydrogenase>250 U/L | 1931 (88.1%) | 1648 (91.0%) | 273 (71.7%) | 0.007 |
| Creatine kinase, U/L | 875 (2288) | 2834 (3850) | 198 (403) | <0.0001 |
| D-dimer, U/L | 7680 (26055) | 10059 (13667) | 5835 (32479) | 0.049 |
| White Cell Blood Count, × 10⁹ per L | 7.82 (5.93) | 7.94 (4.66) | 7.42 (8.94) | 0.270 |
| Lymphocyte Count, × 10⁹ per L | 1.04 (1.84) | 1.12 (2.14) | 0.86(0.52) | 0.001 |
| Lymphocyte Count<1.0 × 10⁹ per L | 1678 (76.6%) | 1484 (82.0%) | 194 (50.9%) | <0.0001 |
| Platelet Count, × 10⁹ per L | 142 (98) | 141 (97) | 146 (100) | 0.410 |
| Platelet Count < 150 × 10⁹ per L | 823 (37.5%) | 675 (37.3%) | 148 (38.8%) | 0.480 |
| P/F ratio | 238 (117) | 203(116) | 406 (68) | <0.0001 |
Data are expressed as mean (standard deviation), median (interquartile range) or n (%).