Table 3. Primary outcome measures in the Per-Protocol group.
| Outcome measure | Timepoint | Education (n = 39^) | Aerobic Exercise (n = 53^) | p-value* |
|---|---|---|---|---|
| Global Amyloid Burden (SUVR) | Baseline | 1.20 (0.2) | 1.23 (0.2) | 0.73 |
| Week 52 | 1.21 (0.2) | 1.24 (0.2) | ||
| Change | 0.01 (0.04) | 0.01 (0.06) | ||
| VO2 peak (mL·kg-1·min-1) | Baseline | 22.7 (5.3) | 22.7 (5.4) | <0.01 |
| Week 52 | 23.0 (4.9) | 25.2 (5.8) | ||
| Change | 0.1 (2.5) | 2.5 (2.4) | ||
| Whole Brain Volume (mL) | Baseline | 1061.7 (114.4) | 1073.6 (109.3) | 0.12 |
| Week 52 | 1059.1 (115.1) | 1068.0 (108.3) | ||
| Change | -2.6 (7.2) | -5.5 (7.6) | ||
| Hippocampal Volume (mL) | Baseline | 7.6 (1.0) | 7.6 (0.7) | 0.31 |
| Week 52 | 7.6 (1.0) | 7.5 (0.7) | ||
| Change | -0.09 (0.14) | -0.06 (0.10) | ||
| Executive Function Composite | Baseline | -0.042 (0.365) | 0.034 (0.392) | 0.90 |
| Week 26 | -0.035 (0.389) | 0.041 (0.606) | ||
| Week 52 | -0.037 (0.452) | 0.012 (0.607) | ||
| Verbal Memory Composite | Baseline | 0.032 (0.822) | 0.024 (0.861) | 0.47 |
| Week 26 | -0.007 (1.014) | -0.039 (0.931) | ||
| Week 52 | 0.051 (0.939) | -0.053 (0.839) | ||
| Visuospatial Composite | Baseline | -0.062 (0.572) | 0.067 (0.657) | 0.22 |
| Week 26 | 0.012 (0.659) | 0.036 (0.727) | ||
| Week 52 | 0.003 (0.559) | 0.017 (0.669) |
Mean (standard deviation). Cognitive composites at Week 26 and Week 52 can be interpreted as change from baseline.
* For amyloid, fitness and brain volume measures, a p-value from ordinary least squares regression adjusted for sex, age, education, and amyloid status comparing the change (baseline to week 52) between the two groups is given. For cognitive measures, a p-value for treatment by time interaction test from linear mixed models adjusted for sex, age, education, and amyloid status among per protocol subgroup is given.
^Sample size for amyloid at baseline and week 52 are Educ:39,35/Exercise:53,53. Sample size for VO2 at baseline and week 52 are Educ:39,34/Exercise:53,53. Sample size for brain volumes at baseline, week 52 are Educ:34,34/Exercise:52,52. Sample sizes for cognitive measures at baseline, week 26, and week 52 are Educ:39,37,36 /Exercise:53,53,53. SUVR = Standard uptake value ratio; VO2 peak = peak oxygen consumption during the graded exercise test.