Fig 3. Incremental predictive ability of polygenic risk scores and C-reactive protein for cardiovascular disease, above conventional risk factors.

Conventional risk factors included age at baseline, sex, smoking status, history of diabetes, systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol. C-index and related changes were estimated using Cox regression, stratified by study centre and sex, adjusted for age at baseline, smoking status, history of diabetes, systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol. 95% confidence intervals (CIs) were estimated using the efficient jackknife approach.