Skip to main content
. 2021 Jan 14;16(1):e0244439. doi: 10.1371/journal.pone.0244439

Fig 4. Lack of SLC15A4 protects mice from developing spontaneous lupus phenotype in NZB/W F1 mice.

Fig 4

NZB/W F1 slc15a4+/+, slc15a4+/-, and slc15a4-/- mice were enrolled at an age of 13 weeks and monitored every two weeks. Survival (A) and proteinuria (B) were monitored throughout the study. Serum was evaluated at indicated times for the presence of anti-dsDNA antibodies (C), anti-histone antibodies (D), IL12p40 (E), and CCL-2 (F). Comparisons were made between wildtype group and knockouts or heterozygous groups *p < 0.05, **p<0.005, ***p<0.0005, N = 4–10 mice per group.