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. Author manuscript; available in PMC: 2021 Jan 14.
Published in final edited form as: Ann Surg Oncol. 2020 May 20;27(11):4475–4485. doi: 10.1245/s10434-020-08608-1

Fig. 4.

Fig. 4

Enrichment plots of Grade 3 BCs showing association with cell proliferation/ cell cycle related gene sets by GSEA compared to Grade 1+2 BCs in the all cohorts. Grade 3 tumors were associated with E2F targets, G2M checkpoint, mTORc1 signaling and MYC targets v1 and v2 (all p<0.001) in the all cohorts. Additional enrichment plots of Grade 3 BCs showing association with immune activity related gene sets by GSEA compared to Grade 1+2 BCs in the METABRIC cohort. Grade 3 tumors were associated with Allograft rejection, INF gamma response, INF alpha response and Inflammatory response (all p<0.001). Similar trends were observed in the TCGA and GSE25066 cohorts.

BC, Breast cancer; GSEA, gene sets enrichment analysis; METABRIC, Molecular Taxonomy of Breast Cancer International Consortium; INF, Interferon; TCGA, the Cancer Genome Atlas; ES, Enrichment score