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. Author manuscript; available in PMC: 2021 Jan 14.
Published in final edited form as: Ann Surg Oncol. 2020 May 20;27(11):4475–4485. doi: 10.1245/s10434-020-08608-1

Fig. 5.

Fig. 5

CIBERSORT demonstrated that high infiltration of Macrophage M1 (p<0.001) and Follicular Helper T cells (p<0.001) in Grade 3 tumors in all cohorts. Infiltration of NK cells was inconsistent between the cohorts although CD8+ T cells were not significantly elevated in Grade 3 tumors. Grade 3 tumors were associated with significantly more TCR diversity (p<0.001), reflecting higher neoantigen load in Grade 3 tumors (p=0.02) in the TCGA cohort. Further, CYT was also significantly elevated in Grade 3 tumors in all cohorts.

NK cells, natural killer cells; TCR, T cell receptors; TCGA, the Cancer Genome Atlas; CYT, cytolytic activity score