Fig. 6.

Grade 3 BCs were associated with significantly higher expression of T cell exhaustion markers, including PD-L1, PD-L2, PD-1, CTLA4, LAG3, IDO1, IDO2, and TIGIT in the METABRIC cohort. Similar trends were observed in the TCGA and GSE25066 cohorts as well.

BC, Breast cancer; PD-L1, programmed death ligand 1; PD-L2, programmed death ligand 2; PD-1, programmed cell death 1; cytotoxic T-lymphocyte-associated antigen 4, CTLA4; LAG3, lymphocyte activating 3; IDO1, indoleamine 2,3-dioxygenase 1; IDO2, indoleamine 2,3-dioxygenase 2; T cell immunoglobulin and ITIM domain, TIGIT; METABRIC, Molecular Taxonomy of Breast Cancer International Consortium; TCGA, the Cancer Genome Atlas