Figure 5.

Effect of MSC on the levels of MDA and nitrite in the sciatic nerves and dorsal root ganglia of mice with OXL-induced chronic neuropathy. Two weeks after the OIPN model induction, mice were treated with 1 × 10⁶ MSC (OXL+MSC) or vehicle (OXL+vehicle) by endovenous route. Control group received 5% dextrose instead of OXL. The levels of MDA and nitrite in the sciatic nerve (a, b, respectively) and DRG (c, d, respectively) were measured 4 weeks after treatment. Data are expressed as means ± standard deviation; n = 6 mice per group. ^∗Statistical significance relative to the control group (p < 0.01); ^#statistical significance relative to the OXL+vehicle group (p < 0.001), as determined by one-way ANOVA followed by Tukey's multiple comparison test.