Table 1.
Effects of oral and rectal administration of different doses of QB extract (200, 400 mg/kg) and sulfasalazine (500 mg/kg) on colonic macroscopic damage (A) and histological score (B) rats' TNBS-induced colitis.
Group | Macroscopic score | Histological score |
---|---|---|
Sham control | 0.55 ± 0.11 | 0.78 ± 0.09 |
Negative control | 4.97 ± 0.26## | 13.1 ± 0.48## |
QB extract 200 mg/kg orally | 3.04 ± 0.21##∗∗ | 9.1 ± 0.37##∗∗ |
QB extract 400 mg/kg orally | 2.17 ± 0.18##∗∗ | 7.95 ± 0.26##∗∗ |
QB extract 200 mg/kg rectally | 1.88 ± 0.33##∗∗ | 7.23 ± 0.15##∗∗ |
QB extract 400 mg/kg rectally | 1.43 ± 0.14##∗∗ | 6.51 ± 0.22##∗∗ |
Sulfasalazine (treated control) | 1.24 ± 0.16∗∗ | 6.12 ± 0.41##∗∗ |
Data are expressed as means ± SEM. ##P < 0.01 vs. sham control; ∗P < 0.05, ∗∗P < 0.01 vs. TNBS control.