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Overview of subpopulations, important receptors, and cytokines produced by NKT cells. Unlike conventional NK cells that mature in the bone marrow, NKT cells develop in the thymus and acquire an invariant or variant TCR, through which their subgroups are stratified. Recent studies show that these lymphocytes participate in the antitumor immune response by recognizing CD1d+ tumors and secreting Th1, Th2, and Th17 profile cytokines.
