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a The spherical, coronaviruses with RNA genome (single-stranded). The genome encodes 4 main structural proteins: spike (S), envelope (E), nucleocapsid (N), and membrane (M) proteins. S contains two subunits S1 for receptor binding and S2 for membrane fusion. b HCQ increases pH in the endosomes thereby, stops their acidification and maturation, and interferes with the entry of the virus in the cell
