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. 2020 Oct 29;40(2):277–291. doi: 10.1038/s41388-020-01525-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Predicted target genes of miR-222-3p using TargetScan, miRDB, and miRWalk and the four overlapping target genes. Correlation analysis between miR-222-3p and HIPK2 using data from B TCGA database and C our center. D The expression of HIPK2 in Panc1 and Mia-PaCa2 cells transfected with empty control or miR-222-3p mimics or inhibitor. E Luciferase activity in HEK-293T cells cotransfected with the HIPK2 wild-type or mutant sequence and miR-222-3p mimics. Correlation analysis between LINC00261 and HIPK2 using data from F TCGA database and G our center. The expression of HIPK2 in H Panc1 and I Mia-PaCa2 cells cotransfected with the LINC00261 overexpression vector and miR-222-3p mimics. The protein levels of the HIPK2/ERK/c-myc axis and c-myc target genes in J Panc1 and K Mia-PaCa2 cells. L Luciferase activity in HEK-293T cells cotransfected with LINC00261 overexpression vector and miR-222-3p mimics. The data are presented as the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01.