Table 2.

Summary of findings (SoF) table for outcomes of harm.

Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	N. of patients		Effect		Certainty
					PMRT	no PMRT	Relative (95% CI)	Absolute (95% CI)
6 sudies; Adjuvant RT; acute grade 3–4 toxicity
Observational	Not serious	Seriousa	Not serious	Not serious	6 studies with 222 events; pooled analysis 11% (95% CI 6.1–17%). I2:97%				Very low
3 studies; Adjuvant RT; late grade 3–4 skin toxicity
Observational	Not serious	Seriousb	Not serious	Not serious	3 studies with 8 events; pooled analysis 0.5% (95% CI 0.1–1%). I2:61%				Very low
3 studies; Adjuvant RT; late grade 3–4 lung toxicity
Observational	Not serious	Seriousa	Not serious	Not serious	3 studies with 49 events; pooled analysis 4.5% (95% CI 1.1–7.8%). I2:97%				Very low
3 studies; Adjuvant RT; late grade 3 lymphedema
Observational	Not serious	Seriousc	Not serious	Not serious	3 studies with 24 events; pooled analysis 1.3% (95% CI 0–2.6%). I2:78%				Very low
2 studies; Adjuvant RT; cardiac events
Observational	Not serious	Seriousd	Not serious	Not serious	2 studies with 24 events; pooled analysis 1.6% (95% CI 0–3.5%). I2:86%				Very low

Abbreviations: RT: radiotherapy; HR: hazard ratio; CI: confidence interval; RR: risk ratio.

Explanations.

^aI2:97%.

^bI2:61%.

^cI2:78%.

^dI2:86%.