Table 2.
Results of liver volume reduction and changes in body weight
| Author | Change in liver volume | Change in weight | Additional liver measurement |
|---|---|---|---|
| Bakker et al. [23] |
Total: − 12.7% LL: − 11.1% |
BMI: − 4.6% | Surgeon scored 31% of the patients with an enlarged liver and 39% had a liver that was fatty with yellow discoloration |
| Chakravartty et al. [22] |
LL: − 23% Control: − 2% |
TWL: − 5.4% FM: 40.3% LBM: 59.7% |
No change in fibrosis, shown by ARFI and APRI |
| No difference in left liver lobe size, sharpness of liver edge, exposure of hiatus and diaphragm from control | |||
| Contreras et al. [12], 800 kcal | Total: − 15.6 ± 11.2% |
TWL: − 5.8% FM: 53.8% LBM: 46.2% |
Liver enzymes: increase in AST and ALT, and unaffected GGT |
| Contreras et al. [12], 1200 kcal | Total: − 12.3 ± 10.6% |
TWL: − 4.2% FM: 49.1% LBM: 50.9% |
Liver enzymes: unaffected AST and ALT, and decreased GGT |
| Edholm et al. [11] | Total: − 12% | TWL: − 6.1% | Intrahepatic fat decreased by 40% from 9.41 ± 6.17% to 5.53 ± 4.11% |
| Surgeon’s perception: decreased left lobe size and better sharpness of liver edge and exposure of hiatal region compared to controls | |||
| Edholm et al. [26] | Total: − 18 ± 4% |
TWL: − 6.5% FM: 71.2% LBM: 28.8% |
Intrahepatic fat decreased by 51 ± 16% |
| Liver volume reduction within the first 2 weeks, no further change afterwards | |||
| Liver enzymes: unaffected AST and ALT | |||
| Ekici et al. [24] |
LL: − 11.2% Control: 0.7% |
TWL: − 4.4% | Not assessed |
| González-Pérez et al. [4] | Total: − 20.3% | EWL: 14.4 ± 5.9% |
Liver volume reduction Week 0–2: − 22%; Week 2–4: − 13%; Week 4–6: +17% |
| Schiavo et al. [25] |
Total: − 26.9% LL: − 29.1% |
TWL: − 16.7% FM: 77% LBM: 23% |
Liver enzymes: decreased GOT and GPT, and unaffected GGT |
ARFI, acoustic-radiation force-impulse imaging; APRI, aspartate aminotransferase to platelet ratio index; AST, aspartate aminotransferase; ALT, alanine transaminase; BMI, body mass index; EWL, excess weight loss; FM, fat mass; GGT, gamma glutamyl transferase; GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; LBM, lean body mass; LL, left liver lobe volume; TWL, total weight loss