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. 2021 Jan 14;11:1324. doi: 10.1038/s41598-020-79397-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Trend in NLR estimates subsequent prognosis after severe irAE. (a) Kaplan-Maier analysis of PFS and (b) OS were performed in patients stratified according to the irAE incidence. (c) Among the patients with irAE development, PFS and (d) OS were investigated according to their irAE severity. (e) Among the patients who experienced Grade 3 or more severe irAEs, PFS and (f) OS were performed in patients stratified according to the NLR trend at 4 weeks after the development of the irAEs. Statistical analysis was performed using the log-rank test. NLR neutrophil-to-lymphocyte ratio, irAE immune-related adverse event, PFS progression-free survival, OS overall survival.