Fig. 1. Sparse partial least squares discriminant analysis (s-PLS-DA) of clinical features differentiating bipolar disorder (BD) from major depressive disorder (MDD).

Left: Two components differentiated BD from MDD. The star plot shows their centroid. The individual patient score on these components are presented as lines radiating from the centroid. Lines representing patients with MDD are shown in blue and lines representing patients with BD are shown in red. The variable weights for each component are presented in Supplementary Table S6. Right: The receiver operating characteristic curve derived from the s-PLS-DA differentiating BD from MDD based on the test samples; area under the curve (AUC) = 0.73, P = 0.001 (additional details in Supplementary Fig. S3A, B).