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. 2021 Jan 14;11:50. doi: 10.1038/s41398-020-01175-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Scatter plot displaying on the Y axis, the t-statistics for associations between module expression in our DLPFC bulk RNA-seq data and the proportion of activated (stage III) microglia and on the X axis t-statistics for module expression and cognitive decline. Each circle represents one module, and the number of the module is listed in each circle. m5 is the module most positively associated with the number of stage III microglia. To illustrate the extent of a module’s enrichment for the HuMiAged microglia signature genes, we have both colored the modules (red being more enriched, blue less enriched) and made the size of the circle proportional to the enrichment (the larger circles such as m116 are more enriched for microglial genes). The t-statistics are derived from linear models adjusted for age, sex, study (ROS or MAP), RNA integrity number (RIN), and postmortem interval. b Scatter plot displaying on the Y axis, the t-statistics for the association of a gene’s expression level and the proportion of activated (stage III) microglia and on the X axis t-statistics for the association of the gene’s expression level and cognitive decline. A subset of genes in module 5 which has extreme results are labeled. All genes belonging to module 5 are in blue with VASP highlighted in red. The t-statistics are derived from linear models adjusted for age, sex, study (ROS or MAP), RIN, and postmortem interval.