Table 3.
Top ten genes in module 5 that are most associated with a combined score for association with activated microglia and cognitive decline.
| Gene | Microglia expression | Bulk expression | P value activated microglia | P value cognitive decline | Combined score |
|---|---|---|---|---|---|
| NBEAL2 | 6.1 | 9.2 | 3.90E-06 | 0.00015 | 8.72 |
| ARRDC2 | 61.5 | 25.5 | 0.021 | 1.90E-08 | 8.06 |
| DDX39A | 99.4 | 28.7 | 0.027 | 3.10E-07 | 7.43 |
| CC2D1B | 15.4 | 20 | 3.60E-05 | 0.0029 | 7.32 |
| VASP | 23.6 | 12.2 | 0.0029 | 2.60E-05 | 7.3 |
| S100A6 | 14.5 | 283 | 0.042 | 2.60E-07 | 7.28 |
| LZTS2 | 16.2 | 34.4 | 0.0018 | 0.00011 | 7.09 |
| MAP3K3 | 22.1 | 25.2 | 0.0038 | 5.90E-05 | 7.02 |
| TRABD | 78 | 13.1 | 0.0059 | 3.70E-05 | 6.98 |
| TBC1D1 | 33.3 | 78.7 | 0.00085 | 0.00046 | 6.97 |
Linear regression analysis was used to associate gene expression to activated microglia for 105 ROSMAP subjects and cognitive decline for the genes in module 5 for all 540 ROSMAP subjects. All the associations were adjusted for age, sex, study (ROS or MAP), RIN, and postmortem interval (PMI). Reported are the average expression in microglia and bulk tissue (FPKM), P value of the associations and the score that was used to combine the P values and rank the genes.