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. 2021 Jan 14;11:1305. doi: 10.1038/s41598-020-80011-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative immunoblots of protein expression levels: (A) liver Bax/Bcl-2 ratio, and liver and serum HMGB1 expression; (B) liver Hp and HO-1 expression; and (C) liver p-Nrf2 and p-NF-κB p65 expression, and p-NF-κB p65/p-Nrf2 ratio. β actin was used as a loading control. The blots cropped from different gels are delineated with the black line (see Supplementary Information). Experimental group abbreviations: S sham-operated rat group, S + M sham-operated + meldonium rat group, I/R ischemia/reperfusion rat group, I/R + M ischemia/reperfusion + meldonium rat group. The number of animals per experimental group: n = 8. Data are given as mean ± standard error of the mean. Minimal significant level: p < 0.05. Significantly different: ^ain respect to S group; ^bin respect to I/R group.