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. 2021 Jan 14;11:1429. doi: 10.1038/s41598-020-80734-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Coordinated expression of _exmiRNAs across chromosomes. (a) Cross correlation of _exmiRNA expression, arranged by chromosomal location, at T_2wk and T_6.5mo for _exmiRNAs with an effect size ≥ 0.40. Individual miRNAs are denoted with MIMAT number and chromosomal location, with “.1” indicative of a chromosomal duplication of the primary miRNA. For corresponding miRNA names, see Table 2. (b) From the full correlation matrices (see Supplementary Fig. S3), we assessed the fold-change difference in the number of significant correlations between chromosomes per number of expressed _exmiRNA on each chromosome. Radar plot shows the enrichment of inter-chromosomal correlation in PAE infants compared to control infants at T_2wk (right) and T_6.5mo (left). Figure (a) was constructed using the corrplot package (version 0.77, https://cran.r-project.org/web/packages/corrplot/index.html) for R (version 3.6.1) and figure (b) was constructed using Excel.