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. 2021 Jan 14;11:1393. doi: 10.1038/s41598-021-81164-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the alternative splicing events in the LNCaP and VCaP models. The number of each type of event derived from the reads of RNA-seq data as described in methods of LNCaP treated with R1881 (AR full length), VCaP treated with R1881, LNCaP- AR-V7 treated with Doxycycline and VCaP-AR-V7 treated with Doxycycline relative to the corresponding vehicle. (a) All events (total); (b) events in regulated genes (DEG), and (c) events in non-regulated genes (non-DEG). A3SS, alternative 3′ splice site; A5SS, alternative 5′ splice site; AFE, alternative first exons; ALE alternative last exons; MXE, mutually exclusive exons; RI, retained introns; SE, skipped exons; Tandem UTR, Tandem 3′UTRs. (d) Overlap of splicing events in the two cell lines and for each AR isoform studied with Bayesian Factor (BF) ≥ 3 and changes in fraction isoform abundance (ψ) between treatment conditions greater than 0.2 (Δψ > 0.2). (e) Overlap of splicing events in the two cell lines and for each AR isoform studied with Bayesian Factor (BF) > 3 and no cut-off for change in fraction isoform abundance (ψ) between treatment conditions (Δψ = 0).