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. 2021 Jan 14;11:1334. doi: 10.1038/s41598-020-79344-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Synaptophysin levels in the cortical and hippocampal area of 6xTg mice brains. Presynaptic receptor proteins (Synaptophysin, 38 kDa) were detected in cortical and hippocampal brain lysates of 2-, 4-, 6-, and 8-month-old WT, JNPL3, 5xFAD, and 6xTg mice by Western blot analysis. (A) Representative Western blots of synaptophysin from cortical and hippocampal brain lysates were shown. In Fig. S5, full-length blots were presented. (B, C) The graph shows the percentage of the density of synaptophysin normalized to GAPDH on Western blot bands from cortical and hippocampal tissue lysates. (B) In the cortex, 4-, 6- and 8-month-old 6xTg mice showed significantly decreased synaptophysin compared with 5xFAD and WT mice. (C) In the hippocampus, 6- and 8-month-old 6xTg mice showed significantly decreased synaptophysin compared with 5xFAD and WT mice. All data are shown as means ± SEM, and each experiment was repeated five times (n = 3 per group). Statistical analyses were performed by one-way ANOVA followed by the Tukey's multiple comparisons test. ****p < 0.0001, ***p < 0.001, **p < 0.01 vs. WT; ^####p < 0.0001, ^###p < 0.001, ^##p < 0.01, ^#p < 0.05 vs. JNPL3; ^$$p < 0.01, ^$p < 0.05 vs. 5xFAD.