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. 2021 Jan 14;11:1399. doi: 10.1038/s41598-021-80999-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SHP2 mediates anti-tumor immunity via IFNγ signaling. (a) scRNAseq data showing IFNγ signaling signature genes expression level change induced by SHP099. (b) ELISA analysis of CXCL10 level in supernatant collected from tumor spheroids treated with IFNγ of gradient concentration in the absence or presence of SHP099 for 6 days. (c) Dose response curve of OVCAR-8 tumor spheroids to IFNγ treatment in the absence or presence of SHP099 after 6 days. (d) Immunoblotting of p-STAT1 and p-ERK in OVCAR-8 tumor spheroids after different treatments. (e) Absolute tumor cell counts from each well of 384-well Elplasia plate after 6 days co-culture of OVCAR-8-sgAAVS1 or OVCAR-8-sgIFNGR1 spheroids with PBMCs. Relative fold change of absolute tumor counts (SHP099 treated over DMSO group) is labeled.