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. 2021 Jan 14;11:1341. doi: 10.1038/s41598-020-78947-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bioluminescence imaging (BLI) of PGK-RLuc and Tet-FLuc signals in three representative NSG mice treated with doxycycline (Dox) on (a, b) day 0, (c, d) day 7, or (e, f) day 11 after tumor transplantation. (b, d, f) The simplified 3-compartment model was fitted (dashed black line) to RLuc signal (white circles), shown superimposed with the predicted population of MYC-On cells (blue line), MYC-Off cells (red line), and Escaped cells (green line). Shaded grey region (below 1.60 × 10⁵ photon/s) indicates imaging signal is below the limit of detection. The model-predicted MYC-expressing tumor cell population (orange line) is shown superimposed with Tet-FLuc signal (yellow squares).