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. 2021 Jan 14;11:1341. doi: 10.1038/s41598-020-78947-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of doxycycline (Dox) treatment to two hypothetical treatments for a simulated lesion of 1 × 10⁷ T-ALL cells. Shown are the MYC-On (blue), MYC-Off (red), and Escaped (green) cell populations following a one-time treatment dosing on the indicated day. Shaded grey region indicates tumor burden not detectable with imaging. Treatment A has a tenfold higher k_netdeath,Off relative to Dox, and Treatment B has a tenfold higher k_netdeath,Off and tenfold lower k_netgr,Esc relative to Dox.