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. 2021 Jan 14;11:1323. doi: 10.1038/s41598-020-79823-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the effects of NT-PGC-1α ablation on diet-induced obesity. (A,B) Measurements of body weight and fat mass of male WT and NT-PGC-1α^−/− mice during chow (n = 11 per group) or HFD (n = 12 per group) feeding. Two-way ANOVA was used to determine the differences between the genotypes. BW: F (1, 24) = 9.726, P = 0.0048; FM: F (1, 22) = 5.939, P = 0.0234 in HFD-fed group. BW: F (1, 22) = 3.485, P = 0.0753; FM: F (1, 20) = 5.843, P = 0.0253 in chow-fed group. (C) Body composition of male WT and NT-PGC-1α^−/− mice after 16 weeks of either chow- or HFD-feeding. Data are presented as the mean ± SEM. *P < 0.05 determined by Student’s t test. (D,E) Body weight and fat mass of female WT and NT-PGC-1α^−/− mice during chow (n = 11 per group) or HFD (n = 12 per group) feeding. Two-way ANOVA was used to determine the differences between the genotypes. BW: F (1, 24) = 20.50, P = 0.0001; FM: F (1, 22) = 21.34, P = 0.0001 in HFD-fed group. BW: F (1, 22) = 0.7853, P = 0.3851; FM: F (1, 20) = 2.426, P = 0.1350 in chow-fed group. (F) Body composition of female WT and NT-PGC-1α^−/− mice after 16 weeks of either chow- or HFD-feeding. Data are presented as the mean ± SEM. **P < 0.01, ***P < 0.001 determined by Student’s t test.