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The area under a curve (AUC) of receiver operating characteristic (ROC) analysis for PD-L1 expression in tumour based on IHC data. ROC analysis revealed that low circulating VEGF, IL-15, and TNF-β levels (all three below the median vs. all other combinations) has significant sensitivity and specificity to discriminate between patients with low and high PD-L1 expression in tumours. The area under the curve (AUC) value of 0.722 (95% CI 0.59–0.85; P = 0.004).
