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. 2021 Jan 14;12(1):84. doi: 10.1038/s41419-020-03356-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Heatmap of the top 20 most upregulated and downregulated genes in LSECs compared to ETV2-ECs. B Heatmap of the top 20 most upregulated and downregulated TFs in LSECs compared to ETV2-ECs. C CenTFinder core analysis results were combined. Each dot represents a TF that was differentially and higher expressed in LSECs compared to ETV2-ECs. In addition, only TFs with kME > 0.5 and NES > 3 were considered. SPI1 was identified as the central TF in the immune response clusters related to cytokine signalling and secretion. IRF TFs were central to the immune response cluster related to inflammasomes. Top TFs are highlighted in red.