Table 2.
Biomarkers in blood of the study groups.
| Blood biomarkers | Survivor group (n = 49) | Nor-survivor group (n = 17) | Total (n = 66) | P value |
|---|---|---|---|---|
| Inflammation | ||||
| hs-CRP (mg/L), median (IQR) | 188.3 (102.9–295.7) | 175.7 (136.5–300.2) | 187.9 (129.8–296.8) | 0.849 |
| PCT (ng/ml), median (IQR) | 28.0 (6.1–95.3) | 29.0 (10.8–102.4) | 28.5 (6.3–97.1) | 0.961 |
| IL-6 (pg/ml), median (IQR) | 217.6 (103.3–962.4) | 4809.0 (247.2–5000.0) | 313.7 (121.3–2565.3) | 0.001* |
| Circulation | ||||
| Lactate (mmol/l), median (IQR) | 2.4 (1.8–3.2) | 6.3 (2.5–14.3) | 2.5 (1.9–4.1) | 0.014* |
| NT-proBNP (ng/ml), median (IQR) | 1596.5 (1708.6–10,635.4) | 32,905.3 (17,942.5–35,000.0) | 3720.1 (880.9–23,665.7) | < 0.001* |
| Tn-I (ng/ml), median (IQR) | 0.0 (0.01–0.12) | 0.2 (0.01–0.98) | 0.01 (0.01–0.31) | 0.953 |
| Renal function | ||||
| Cr (μmol/l), median (IQR) | 125.0 (92.0–247.0) | 252.0 (239.0–463.0) | 170.0 (103.0–281.0) | 0.215 |
| Liver function | ||||
| Total bilirubin (μmol/l), median (IQR) | 13.8 (5.0–70.9) | 14.8 (8.3–110.9) | 14.0 (6.0–88.9) | 0.505 |
| Coagulation function | ||||
| PLT (× 109/l), mean (SD) | 170.6 (109.5) | 167.4 (110.5) | 169.7 (108.0) | 0.919 |
| PT (s), median (IQR) | 15.6 (13.2–17.4) | 20.1 (16.9–25.2) | 16.2 (14.0–19.5) | 0.030* |
| APTT (s), median (IQR) | 45.1 (38.5–55.3) | 59.0 (46.8–90.5) | 49.0 (42.2–58.0) | 0.026* |
| Fib (g/l), median (IQR) | 5.1 (4.2–7.7) | 5.7 (2.2–6.2) | 5.1 (4.1–7.3) | 0.882 |
| INR, median (IQR) | 1.3 (1.1–1.5) | 1.8 (1.5–3.8) | 1.4 (1.2–1.8) | < 0.001* |
| d-Dimer (μg/l), median (IQR) | 3948.5 (2093.5–7848.0) | 8889.4 (4278.9–10,000.0) | 4765.9 (2792.7–8716.9) | 0.717 |
IQR range interquartile, hs-CRP high-sensitivity C-reactive protein, PCT procalcitonin, IL-6 Interleukin 6, NT-proBNP N-terminal prohormone of brain natriuretic peptide, Tn-I Troponin I, Cr creatinine, PLT Platelet, PT prothrombin time, APTT activated partial thrombin time, Fib fibrinogen, INR international normalized ratio.
*Indicates a significant value, P < 0.05.