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. 2021 Jan 14;12(1):85. doi: 10.1038/s41419-020-03370-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A CYH33-resistant cells were treated with MEK162/RAD001/OTX015 and CYH33 alone or in combination for 72 h. Cell proliferation was measured with SRB assay and combination index (CI) values were calculated by Calcu Syn software (n = 3). B–D CYH33-resistant cells were treated with CYH33 (1 μM, 1 h), MEK162 (1 μM, 1 h) (B), RAD001 (1 μM, 1 h) (C), or OTX015 (1 μM, 24 h) (D) alone or in combination. Cell lysates were then subjected to western blotting with indicated antibodies. Data shown are from at least two independent experiments. C: CYH33, M: MEK162, R: RAD001, O: OTX015.