Available (black) and theoretical (red) interventions to combat arboviral disease. Physical barriers, pesticides, repellants, and attractants/traps are the only methods available to prevent arboviral diseases. Supportive care is the only treatment option available in most cases. The development of a traditional vaccine for dengue virus has been problematic due to antibody-dependent enhancement. New research has paved the way for vector-based interventions including acquisition- and transmission-blocking vaccines and therapeutics, biological control agents, and the release of genetically altered, sterile mosquitoes.