. 2021 Jan 15;11:6. doi: 10.1038/s41387-021-00149-0

Table 1.

Change from baseline in body weight and fasting blood glucose in study completers.

	12:12 Schedule	14:10 Schedule	LS mean difference
Completers population	(n = 30)	(n = 30)
Baseline body weight (kg)	121.3 ± 19.1	124.4 ± 20.5	–
95% CI	(114.3, 128.4)	(116.9, 132.0)
Week 8 body weight (kg)	112.6 ± 18.1	113.8 ± 18.9	–
95% CI	(105.9, 119.3)	(106.8, 120.8)
Week 8 change in body weight (kg)^a	−8.9 ± 4.2	−10.7 ± 4.1	1.9 ± 4.5
95% CI	(−10.4, −7.3)	(−12.3, −9.2)	(0.2, 3.5)
P value	<0.0001	<0.0001	0.025
Week 8 change in body weight (kg)^b	−5.4 ± 2.5	−6.8 ± 3.0	1.5 ± 3.6
95% CI	(−6.3, −4.5)	(−7.9, −5.7)	(0.1, 2.8)
P value	<0.0001	<0.0001	0.032
Week 8 change in body weight (%)^a	−7.1 ± 3.4	−8.5 ± 3.0	1.4 ± 3.5
95% CI	(−8.3, −5.8)	(−9.6, −7.4)	(0.2, 2.7)
P value	<0.0001	<0.0001	0.027
Week 8 change in body weight (%)^b	−5.0 ± 1.9	−6.0 ± 1.8	1.0 ± 2.4
95% CI	(−5.7, −4.3)	(−6.7, −5.4)	(0.2, 1.9)
P value	<0.0001	<0.0001	0.020
Baseline FBG (mg/dl)	101.5 ± 19.7	102.2 ± 23.6	–
95% CI	(94.3, 108.8)	(93.6, 110.9)
Week 8 FBG (mg/dl) 95% CI	98.9 ± 14.4 (93.6, 104.2)	95.2 ± 12.9 (90.4, 100.0)	–
Week 8 change in FBG (mg/dl)^a	−3.1 ± 18.5	−7.6 ± 20.3	4.5 ± 21.3
95% CI	(−10.0, 3.7)	(−15.1, −0.1)	(−3.3, 12.3)
P value	0.36	0.047	0.23
Week 8 change in FBG (mg/dl)^b	−9.6 ± 13.1	−11.0 ± 16.6	1.5 ± 17.6
95% CI	(−14.3, −4.8)	(−17.1, −5.0)	(−5, 7.9)
P value	<0.0001	<0.0001	0.65
FBG ≥ 100 mg/dl at baseline (Completers)	n = 12	n = 12
Baseline FBG (mg/dl)	113.6 ± 8.7	117.3 ± 21.8	–
95% CI	(108.1, 119.1)	(103.5, 131.0)
Week 8 FBG (mg/dl)	101.7 ± 12.7	99.1 ± 13.5	–
95% CI	(93.8, 109.6)	(90.7, 107.6)
Week 8 change (mg/dl)^a	−11.2 ± 15.8	−17.6 ± 19.3	6.4 ± 22.4
95% CI	(−21.0, −1.4)	(−29.8, −5.5)	(−7.1, 20.0)
P value	0.029	0.008	0.33

Data are LS mean ± SD.

FBG fasting blood glucose.

^aANOVA of the change from baseline to Week 8.

^bANOVA of the change from baseline using repeated measures method that included all postbaseline measurements.