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. 2021 Jan 14;11:1310. doi: 10.1038/s41598-020-79479-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological examination of rat liver. (A) Negative control group. (B) CeNPs group. (C–E) FIP group showing in (C) congested central vein (arrow), massive fatty degeneration in the periportal areas (arrowheads) and lymphocytic aggregation (arrow) in between massive fatty degeneration (arrowheads). (D) Highly congested portal vein surrounded with lymphocytic infiltration (arrowhead). (E) Necrotic foci (thick arrow), congested liver sinusoids (arrowheads) and fatty degeneration (thin arrows). (F) FIP group that treated with CeNPs. Scale bar = 50 µm. (G) H&E semi quantitative scoring of hepatic fatty degeneration and lymphocytic aggregations. Data expressed as Mean ± SE, analyzed using one-way ANOVA at P ≤ 0.05, column with different letters (a, b & c) indicate significant difference among the values of different groups.