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. 2021 Jan 14;11:1375. doi: 10.1038/s41598-020-80469-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immune-electronmicroscopy of cortactin in spines of distal PC branchlets. (A–C) Robust postsynaptic DAB reaction product (blue pseudo-color) in Purkinje-cell dendrites (d), and spines (*) (parallel fiber terminals (PFt) seen in orange pseudo-color). Arrowheads point to accumulated patches of immunoperoxidase reaction product at submembrane regions. (D_1–4) Immunogold label coding for cortactin. Dendritic spines of PCs (blue pseudo-color); cortactin-coding immunogold particles may be seen in the periphery of spines associated with synaptic membranes, non-synaptic membranes, and submembrane spinoplasm (arrowheads). (E,F) Immunogold particles coding for synaptophysin (E) may be seen labelling presynaptic terminals. In contrast, PSD-95 (F) label is restricted to the postsynaptic density of PC spines. Scale bar: (A): 500 nm, and (B–F): 250 nm.

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